6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

Base Information

Chemical Name:6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine
CAS No.:1416337-01-3
Molecular Formula:C₁₅H₂₁BrN₄O
Molecular Weight:353.262
Hs Code.:

Synonyms:6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

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Chemical Property of 6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

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Technology Process of 6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

There total 1 articles about 6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 1416337-01-3
6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 20 °C

2: sodium dithionite / ethanol; water / 20 °C

3: methanol / 20 °C

With sodium dithionite; potassium carbonate; In methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield: 18.87%

: 1366132-81-1
N-(4-fluorophenyl)-2-(methyloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinesulfonamide

: 1416337-01-3
6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

: 1416333-56-6
5-(2-amino-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-6-yl)-N-(4-fluorophenyl)-2-(methyloxy)-3-pyridinesulfonamide

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 90 ℃; for 3h;

Reference yield: 16.15%

: 64-18-6
formic acid

: 1383992-93-5
N-(3-fluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide

: 1416337-01-3
6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine

: 5-(2-amino-1-((4-(dimethylamino)tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-6-yl)-N-(3-fluorophenyl)-2-methoxypyridine-3-sulfonamide formic acid salt

Guidance literature:: N-(3-fluorophenyl)-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide; 6-bromo-1-{[4-(dimethylamino)tetrahydro-2H-pyran-4-yl]methyl}-1H-benzimidazol-2-amine; With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 130 ℃; for 0.25h; Microwave irradiation;

formic acid; In water; N,N-dimethyl-formamide; acetonitrile;