(2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

Base Information

Chemical Name:(2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole
CAS No.:417704-45-1
Molecular Formula:C₃₃H₃₂N₈O₅
Molecular Weight:620.668
Hs Code.:

Synonyms:(2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

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Chemical Property of (2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

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Technology Process of (2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

There total 6 articles about (2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 136465-98-0
(2S)-2-[(quinoline-2-carbonyl)-amino]-succinamic acid

: (2S)-5-[2-amino-3-phenylpropyl]-1-(benzyloxycarbonylmethyl)-1H-tetrazole hydrobromide

: 417704-45-1
(2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 15196-02-8
(S)-3-[(benzyloxycarbonyl)amino]-1-diazo-4-phenyl-2-butanone

: 417704-45-1
(2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N / acetonitrile / 24 h / Irradiation

2: PCl₅; quinoline / CHCl₃ / 2.5 h / 20 °C

3: 300 mg / hydrazoic acid / CHCl₃; benzene / 48 h / 20 °C

4: 99 percent / aq. AcOH; HBr / 0.5 h / 20 °C

5: 51 percent / BOP; Et₃N / dimethylformamide / 18 h / 20 °C

With quinoline; hydrogen azide; phosphorus pentachloride; hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; In chloroform; N,N-dimethyl-formamide; acetonitrile; benzene; 1: Wolff rearrangement;

Reference yield:

: 2462-31-9
benzyl 2-aminoacetate hydrochloride

: 417704-45-1
(2S)-1-(benzyloxycarbonylmethyl)-5-[3-phenyl-2-(quinolin-2-ylcarbonyl-L-asparaginylamino)propyl]-1H-tetrazole

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N / acetonitrile / 24 h / Irradiation

2: PCl₅; quinoline / CHCl₃ / 2.5 h / 20 °C

3: 300 mg / hydrazoic acid / CHCl₃; benzene / 48 h / 20 °C

4: 99 percent / aq. AcOH; HBr / 0.5 h / 20 °C

5: 51 percent / BOP; Et₃N / dimethylformamide / 18 h / 20 °C

With quinoline; hydrogen azide; phosphorus pentachloride; hydrogen bromide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; triethylamine; In chloroform; N,N-dimethyl-formamide; acetonitrile; benzene; 1: Wolff rearrangement;