cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Base Information

Chemical Name:cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine
CAS No.:1357001-62-7
Molecular Formula:C₂₄H₂₈FN₃
Molecular Weight:377.505
Hs Code.:

Synonyms:cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Suppliers and Price of cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

There total 2 articles about cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 576-16-9
5-fluorotryptamine

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: 1357001-62-7
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: 5-fluorotryptamine; 4-dimethylamino-4-phenylcyclohexanone; In ethanol; for 12h; Reflux;

With trifluoroacetic acid; In 1,2-dichloro-ethane; at 20 ℃; for 12h;

With sodium hydroxide; In 1,2-dichloro-ethane; at 0 ℃; Basic conditions;

Reference yield:

: 65619-19-4
4-dimethylamino-4-phenylcyclohexanone, ethylene ketal hydrochloride

: 1357001-62-7
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: ethanol / 12 h / Reflux

2.2: 12 h / 20 °C

2.3: 0 °C / Basic conditions

With hydrogenchloride; water; In ethanol;

Reference yield: 21.0%

: 1357001-62-7
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 1357001-76-3
cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine; Cinnamoyl chloride; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; water; for 1.5h; cooling with ice;