cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Base Information

Chemical Name:cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine
CAS No.:1357001-76-3
Molecular Formula:C₃₃H₃₄FN₃O
Molecular Weight:507.651
Hs Code.:

Synonyms:cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Chemical Property of cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

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Technology Process of cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

There total 3 articles about cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1357001-62-7
cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 1357001-76-3
cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: cis-6'-fluoro-2',3',4',9'-tetrahydro-N,N-dimethyl-4-(phenyl)spiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine; Cinnamoyl chloride; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

With sodium hydroxide; In tetrahydrofuran; water; for 1.5h; cooling with ice;

Reference yield:

: 65619-19-4
4-dimethylamino-4-phenylcyclohexanone, ethylene ketal hydrochloride

: 1357001-76-3
cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; water / 96 h / 20 °C

1.2: cooling with ice

2.1: ethanol / 12 h / Reflux

2.2: 12 h / 20 °C

2.3: 0 °C / Basic conditions

3.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

3.2: 1.5 h / cooling with ice

With hydrogenchloride; water; sodium hydroxide; In tetrahydrofuran; ethanol;

Reference yield:

: 576-16-9
5-fluorotryptamine

: 65619-20-7
4-dimethylamino-4-phenylcyclohexanone

: 1357001-76-3
cis-(E)-2',3',4',9'-tetrahydro-N,N-dimethyl-6'-fluoro-4-phenyl-2'-(2-phenylvinyl)carbonylspiro[cyclohexane-1,1'(1'H)-pyrido[3,4-b]indole]-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 12 h / Reflux

1.2: 12 h / 20 °C

1.3: 0 °C / Basic conditions

2.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2.2: 1.5 h / cooling with ice

With sodium hydroxide; In tetrahydrofuran; ethanol;