tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

Base Information

Chemical Name:tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate
CAS No.:1332758-69-6
Molecular Formula:C₂₂H₂₆FN₅O₄S
Molecular Weight:475.544
Hs Code.:

Synonyms:tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

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Chemical Property of tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

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Technology Process of tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

There total 6 articles about tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332758-51-6
4-(2-(1-(tert-butoxycarbonylamino)propan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

: 1332758-69-6
tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

Guidance literature:: 4-(2-(1-(tert-butoxycarbonylamino)propan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With ammonia; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1332758-69-6
tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

4.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 2 h

With methanol; di-tert-butyl-diazodicarboxylate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;

Reference yield:

: 95656-86-3,119768-44-4,138457-45-1
tert-butyl 2-hydroxypropylcarbamate

: 1332758-69-6
tert-Butyl 2-(2-(6-carbamoyl-5-methyl-thieno[2,3-d]pyrimidin-4-ylamino)-5-fluorophenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

4.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 2 h

With methanol; di-tert-butyl-diazodicarboxylate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;