Chemical Property of Tributyrin
Chemical Property:
- Appearance/Colour:colourless liquid
- Vapor Pressure:0.000722mmHg at 25°C
- Melting Point:-75 °C
- Refractive Index:n20/D 1.435(lit.)
- Boiling Point:307.499 °C at 760 mmHg
- Flash Point:143.415 °C
- PSA：78.90000
- Density:1.054 g/cm3
- LogP:2.38490
- Storage Temp.:Store at RT.
- Solubility.:H2O: insoluble
- Water Solubility.:Not miscible in water.
- XLogP3:2.4
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:14
- Exact Mass:302.17293854
- Heavy Atom Count:21
- Complexity:304
- Purity/Quality:
-
98% *data from raw suppliers
Glycerol Tributyrate *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC
- Recent ClinicalTrials:Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Tributyrin Supplementation
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Description
Tributyrin (C15H26O6), also known as butyrin or glyceryl tributyrate, is the triester of glycerin and butyric acid. It is prepared by esterifcation of glycerin with excess butyric acid. Glycerol tributyrate has a characteristic odor and a bitter taste.Tributyrin is essentially a triacylglyceride (TAG), which is an ester derived from glycerol and 3 fatty acids. Tributyrin requires lipase to release the butyrate attached to the glycerol. Although 1 tributyrin contains 3 butyrate, not all 3 butyrate is guaranteed to be released. This is because lipase is regioselective. It can hydrolyse triacylglycerides at R1 and R3, only R2, or non-specifically. Lipase also has substrate specificity in that the enzyme can differentiate between acyl chains attached to the glycerol and preferentially cleaving certain types. Since tributyrin requires lipase to release its butyrate, there may be competition between tributyrin and other TAGs for lipase.
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Uses
Tributyrin is a stable and rapidly absorbed prodrug of butyric acid which enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. Tributyrin is a flavoring agent that is the triester of glycerin and
butyric acid. it is prepared by esterification of glycerin with excess
butyric acid. it is used in the following foods: baked goods; alcoholic
beverages; nonalcoholic beverages; fats and oils; frozen dairy des-
serts and mixes; gelatins, puddings and fillings; and soft candy. it is
also termed butyrin and glyceryl tributyrate.
