Sodium Butyrate

Base Information

• Chemical Name: Sodium Butyrate
• CAS No.: 156-54-7
• Molecular Formula: C4H8O2.Na
• Molecular Weight: 110.088
• Hs Code.: 29156000
• European Community (EC) Number: 205-857-6
• UNII: 8RAS91C36W
• ChEMBL ID: CHEMBL62381
• DSSTox Substance ID: DTXSID3037672
• NCI Thesaurus Code: C2337
• Nikkaji Number: J21.150H
• Wikidata: Q305004
• Wikipedia: Sodium_butyrate
• Mol file: 156-54-7.mol

Synonyms:Butanoicacid, sodium salt (9CI);Butyric acid, sodium salt (6CI,8CI);Butyrate sodium;Sodium n-butyrate;Sodium propanecarboxylate;

Chemical Property of Sodium Butyrate

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 1.35mmHg at 25°C
• Melting Point: 250-253 ºC
• Boiling Point: 164.3 ºC at 760 mmHg
• Flash Point: 69.7 ºC
• PSA: 40.13000
• Density: 0.987 g/cm³
• LogP: -0.46360
• Storage Temp.: -20°C
• Sensitive.: Hygroscopic
• Solubility.: Methanol (Slightly), Water (Slightly)
• Water Solubility.: soluble
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 110.03437374
• Heavy Atom Count: 7
• Complexity: 53.7

Purity/Quality:

99% ^*data from raw suppliers

Sodium Butyrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-68
• Safety Statements: 37/39-26-24/25-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Metals -> Organic Acids, Metal Salts
• Canonical SMILES: CCCC(=O)[O-].[Na+]
• Recent ClinicalTrials: Gut Butyrate and Blood Pressure in African Americans
• Recent EU Clinical Trials: Naburen enema for prevention of radiation proctitis. A multicentre randomised placebo-controlled dose-finding phase II study to evaluate efficacy, tolerability, acceptability and compliance with enema in patients undergoing radical radiotherapy for prostate cancer
• Uses: Sodium butyrate is a compound with formula Na(C3H7COO). It is the sodium salt of butyric acid. It has various effects on cultured mammalian cells including inhibition of proliferation, induction of differentiation and induction or repression of gene expre Sodium Butyrate is an inhibitor of histone deacetylase activity (HDAC) resulting in improvement of physiological disorders such as Duchenne muscular dystropy. In addition it is a possible antitumor agent when used in conjunction with other cytotoxic agents as they have been shown to treat carcinomas. Sodium butyrate has been used:as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.

Technology Process of Sodium Butyrate

There total 8 articles about Sodium Butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium 4-n-butanoyloxybenzyl phenoxycarbonylphosphonate → (4-hydroxyphenyl)methanol (623-05-2) + sodium butyrate (156-54-7) + 4-butanoyloxybenzyl disodium carbonylphosphonate + phenol (108-95-2,27073-41-2)

Guidance literature:

With sodium methylphosphonate buffer; at 37 ℃; for 168h; Rate constant;

DOI:10.1016/0040-4020(96)00906-4

Reference yield:

propionyl chloride (79-03-8) → sodium proprionate (137-40-6) + sodium butyrate (156-54-7)

Guidance literature:

propionyl chloride; With hydrogen fluoride; Electrochemical reaction;

With sodium hydroxide; In water;

DOI:10.1016/j.jfluchem.2010.12.004

Reference yield:

acetic butyric anhydride (7165-13-1) → sodium acetate (127-09-3) + sodium butyrate (156-54-7)

Guidance literature:

With water; sodium hydroxide; at 50 ℃; for 0.00277778h; pH=12.8; Overall yield = >= 95 %Spectr.;

upstream raw materials:

butyraldehyde

sodium butanolate

tetrachloromethane

water

Downstream raw materials:

2-ethyl-3t-[2]furyl-acrylic acid

1,4-Dibutyryloxy-buten-(2)

butanoic acid anhydride

butyl butyrate

Refernces

• 1、 Rangarajan,Sathyamoorthi,Velayutham,Noel,Singh,Brahma, Raju. "Products formed at intermediate stages of electrochemical perfluorination of propionyl and n-butyryl chlorides. Further evidence in support of NiF 3 mediated free radical pathway". experimental part. p. 107 - 113. Retrieved 2011/03/23.
• 2、 Briggs, Andrew D.,Camplo, Michel,Freeman, Sally,Lundstroem, Jan,Pring, Brian G.. "Acyloxymethyl and 4-acyloxybenzyl diester prodrugs of phosphonoformate". . p. 14937 - 14950. Retrieved 2007/10/03.