4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

Base Information

Chemical Name:4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone
CAS No.:634902-30-0
Molecular Formula:C₂₂H₃₂N₂O₃
Molecular Weight:372.508
Hs Code.:

Synonyms:4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

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Chemical Property of 4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

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Technology Process of 4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

There total 3 articles about 4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.1%

: 118971-01-0
(S)-(-)-2-(1-methoxy-1-ethylpropyl)-pyrrolidine

: 634902-32-2
1-(4-methoxybenzyl)pyrrolidine-2,4-dione

: 634902-30-0
4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

Guidance literature:: With pyridinium p-toluenesulfonate; In benzene; for 24h; Heating;
DOI:10.1021/ol035617a

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 634902-30-0
4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

Guidance literature:: Multi-step reaction with 3 steps

1: 75.4 percent / triethylamine / acetonitrile / 4 h / Heating

2: 75 percent / hydrochloric acid / 5 h / 20 °C

3: 50.1 percent / pyridinium p-toluenesulfonate / benzene / 24 h / Heating

With hydrogenchloride; pyridinium p-toluenesulfonate; triethylamine; In acetonitrile; benzene;
DOI:10.1021/ol035617a

Reference yield:

: 634902-31-1
4-methoxy-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

: 634902-30-0
4-[(S)-2-(1-methoxy-1-ethylpropyl)pyrrolidin-1-yl]-1-(4-methoxybenzyl)-2,5-dihydro-1H-2-azolone

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / hydrochloric acid / 5 h / 20 °C

2: 50.1 percent / pyridinium p-toluenesulfonate / benzene / 24 h / Heating

With hydrogenchloride; pyridinium p-toluenesulfonate; In benzene;
DOI:10.1021/ol035617a