Technology Process of 2-methyl-6-[3-(6-methylpyridin-2-yl)-1,3-diphenylpropa-1,2-dienyl]pyridine
There total 8 articles about 2-methyl-6-[3-(6-methylpyridin-2-yl)-1,3-diphenylpropa-1,2-dienyl]pyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
phenylmagnesium chloride;
With
zinc(II) chloride;
In
tetrahydrofuran; diethyl ether;
at 20 ℃;
for 0.666667h;
C23H20N2O2;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
at -40 - -10 ℃;
for 16h;
Further stages.;
DOI:10.1002/ejic.200701049
- Guidance literature:
-
phenylmagnesium bromide;
With
zinc dibromide;
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 0.5h;
Inert atmosphere;
C28H22N2O2;
With
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; diethyl ether;
at 0 ℃;
for 3h;
Inert atmosphere;
DOI:10.1039/d0dt00665c
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
3.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 5 h / 20 °C / Inert atmosphere
4.1: triethylamine; dmap / dichloromethane / 0 - 20 °C / Inert atmosphere
5.1: zinc dibromide / tetrahydrofuran; diethyl ether / 0.5 h / 0 °C / Inert atmosphere
5.2: 0.5 h / 0 °C / Inert atmosphere
With
dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; triethylamine; zinc dibromide;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1039/d1dt02929k
