di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate
CAS No.:180839-20-7
Molecular Formula:C₂₈H₃₄N₂O₁₁
Molecular Weight:574.585
Hs Code.:

Synonyms:di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

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Chemical Property of di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Chemical Property:

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Technology Process of di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

There total 7 articles about di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 180839-19-4
di-tert-butyl N-<(4-phenoxy)carbonyl>-L-glutamate

: 180839-20-7
di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Guidance literature:: With triethylamine; In tetrahydrofuran; for 1h; Ambient temperature;
DOI:10.1021/jm980425k

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 180839-20-7
di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / toluene / 0.83 h / Ambient temperature

2: 72.7 percent / Et₃N / toluene / 12 h / 20 °C

3: 81 percent / Hg(ClO₄)2*3H₂O / CHCl₃; tetrahydrofuran / 0.08 h

4: 86 percent / sodium cyanoborohydride / acetic acid; methanol; H₂O / 1 h / Ambient temperature

5: 41 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

With mercury(II) perchlorate; sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; chloroform; water; acetic acid; toluene;
DOI:10.1021/jm980425k

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 180839-20-7
di-tert-butyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenoxy)carbonyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Et₃N / CHCl₃ / 2 h / Heating

2: 86 percent / sodium cyanoborohydride / acetic acid; methanol; H₂O / 1 h / Ambient temperature

3: 41 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

With sodium cyanoborohydride; triethylamine; In tetrahydrofuran; methanol; chloroform; water; acetic acid;
DOI:10.1021/jm980425k