2-hydroxy-2-phenyl-1-thiocyanatopropane

Base Information

• Chemical Name: 2-hydroxy-2-phenyl-1-thiocyanatopropane
• CAS No.: 78508-39-1
• Molecular Formula: C₁₀H₁₁NOS
• Molecular Weight: 193.269
• Mol file: 78508-39-1.mol

Synonyms:2-hydroxy-2-phenyl-1-thiocyanatopropane

Chemical Property of 2-hydroxy-2-phenyl-1-thiocyanatopropane

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-hydroxy-2-phenyl-1-thiocyanatopropane

There total 5 articles about 2-hydroxy-2-phenyl-1-thiocyanatopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ammonium thiocyanate (1147550-11-5) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → 2-hydroxy-2-phenyl-1-thiocyanatopropane (78508-39-1)

Guidance literature:

In acetonitrile; at 0 ℃; for 2h; Irradiation; Green chemistry;

DOI:10.1039/d1nj01752g

Reference yield: 61.0%

ammonium thiocyanate (1147550-11-5) + isopropenylbenzene (98-83-9,6144-04-3,25014-31-7,42612-14-6) → (1-methyl-1,2-dithiocyanatoethyl)benzene (60212-11-5) + C10H11NO2S + 2-hydroxy-2-phenyl-1-thiocyanatopropane (78508-39-1) + acetophenone (98-86-2)

Guidance literature:

With oxygen; rose bengal; benzoic acid; In acetonitrile; at 20 ℃; for 12h; Reagent/catalyst; Solvent; Wavelength; Time; Mechanism; Irradiation; Green chemistry;

DOI:10.1016/j.tet.2018.05.007

Reference yield: 42.0%

2-methyl-2-phenyloxirane (2085-88-3) + Triphenylphosphin, Thiocyansaeure → 2-hydroxy-2-phenyl-1-thiocyanatopropane (78508-39-1)

Guidance literature:

In dichloromethane; 1.) -40 deg C, 4 h, 2.) room temperature;

DOI:10.1039/P19810001577

upstream raw materials:

2-methyl-2-phenyloxirane

isopropenylbenzene

ammonium thiocyanate

potassium thioacyanate