Technology Process of diethyl 5-fluoro-2,4-dinitrobenzoylmalonate
There total 4 articles about diethyl 5-fluoro-2,4-dinitrobenzoylmalonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / nitric acid (d=1.42), conc. sulphuric acid / 1.) not over 35 deg C; 2.) 30 min, room temp.
2: 53 percent / conc. sulphuric acid, anhydrous chromic acid / H2O / 1.) 20 min, -6 deg C - 0 deg C; 2.) room temp., 3.5 h.
3: 75 percent / SOCl2 / 2.5 h / Heating
4: 1.) Mg / 1.) C2H5OH, CCl4, ether; 2.) THF, 20 min 4 deg C - 18 deg C, 1 h room temp.
With
thionyl chloride; sulfuric acid; nitric acid; chromic acid; magnesium;
In
water;
DOI:10.1002/jhet.5570240134
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 53 percent / conc. sulphuric acid, anhydrous chromic acid / H2O / 1.) 20 min, -6 deg C - 0 deg C; 2.) room temp., 3.5 h.
2: 75 percent / SOCl2 / 2.5 h / Heating
3: 1.) Mg / 1.) C2H5OH, CCl4, ether; 2.) THF, 20 min 4 deg C - 18 deg C, 1 h room temp.
With
thionyl chloride; sulfuric acid; chromic acid; magnesium;
In
water;
DOI:10.1002/jhet.5570240134
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 75 percent / SOCl2 / 2.5 h / Heating
2: 1.) Mg / 1.) C2H5OH, CCl4, ether; 2.) THF, 20 min 4 deg C - 18 deg C, 1 h room temp.
With
thionyl chloride; magnesium;
DOI:10.1002/jhet.5570240134
