N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid

Base Information

• Chemical Name: N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid
• CAS No.: 121583-57-1
• Molecular Formula: C₁₄H₁₃Cl₃F₂N₄O₃S
• Molecular Weight: 461.704
• Mol file: 121583-57-1.mol

Synonyms:N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid

Chemical Property of N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid

There total 3 articles about N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-difluorobenzene-1-sulfonamide (60230-37-7) → N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid (121583-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / conc. HCl / 16 h / Heating

2: SOCl₂ / 2 h / Heating

3: Et₃N / toluene / 18 h / Ambient temperature

With hydrogenchloride; thionyl chloride; triethylamine; In toluene;

DOI:10.1007/BF00810285

Reference yield:

N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid (121583-28-6) → N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid (121583-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / toluene / 18 h / Ambient temperature

With thionyl chloride; triethylamine; In toluene;

DOI:10.1007/BF00810285

Reference yield:

2-amino-6-methoxy-4-methylpyrimidine (7749-47-5) + 2,6-Difluoro-N-(1,2,2,2-tetrachloro-ethyl)-benzenesulfonamide → N-<(4-Methoxy-6-methylpyrimidin-2-ylamino)-2,2,2-trichlorethyl>-2,6-difluorbenzolsulfonsaeureamid (121583-57-1)

Guidance literature:

With triethylamine; In toluene; for 18h; Yield given; Ambient temperature;

DOI:10.1007/BF00810285

upstream raw materials:

2-amino-6-methoxy-4-methylpyrimidine

2,6-difluorobenzene-1-sulfonamide

N-(2,2,2-Trichlor-1-hydroxyethyl)-2,6-difluorbenzolsaeureamid