(1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester

Base Information

• Chemical Name: (1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester
• CAS No.: 119945-35-6
• Molecular Formula: C₂₂H₃₆O₄
• Molecular Weight: 364.525
• Mol file: 119945-35-6.mol

Synonyms:(1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester

Chemical Property of (1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester

There total 4 articles about (1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester (119909-63-6,119945-34-5) → (1S,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester (119909-64-7) + (1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester (119945-35-6)

Guidance literature:

In diethyl ether; at 23 ℃; for 0.0833333h;

DOI:10.1021/ja00188a054

Reference yield:

(1R,2R)-cyclopentane-1,2-dicarboxylic acid mono-(+)-menthyl ester (119909-62-5) → (1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester (119945-35-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -25 deg C, 1 h, 2.) 23 deg C, 16 h

2: 19 percent / diethyl ether / 0.08 h / 23 °C

With lithium diisopropyl amide; In diethyl ether;

DOI:10.1021/ja00188a054

Reference yield:

(+)-Dimenthyl (1R,2R)-cyclopentane-1,2-dicarboxylate (96149-02-9) → (1R,2R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester (119945-35-6)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH, 30percent H₂O₂ / methanol / 14 h / 50 °C

2: 1.) LDA / 1.) THF, -25 deg C, 1 h, 2.) 23 deg C, 16 h

3: 19 percent / diethyl ether / 0.08 h / 23 °C

With potassium hydroxide; dihydrogen peroxide; lithium diisopropyl amide; In methanol; diethyl ether;

DOI:10.1021/ja00188a054

upstream raw materials:

diazomethane

(R)-1-(2-Methyl-allyl)-cyclopentane-1,2-dicarboxylic acid 1-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester

(1R,2R)-cyclopentane-1,2-dicarboxylic acid mono-(+)-menthyl ester

3-Chloro-2-methylpropene