5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

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Chemical Name:5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine
CAS No.:1361569-72-3
Molecular Formula:C₁₉H₁₂F₂N₆
Molecular Weight:362.341
Hs Code.:

Synonyms:5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

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Chemical Property of 5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

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Technology Process of 5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

There total 6 articles about 5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1350653-24-5
5-fluoro-1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine

: 335654-06-3
2-chloro-7H-pyrrolo[2,3-d]pyrimidine

: 1361569-72-3
5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-n-butyltin); In 1,4-dioxane; for 60h; Inert atmosphere; Reflux;

Reference yield:

: 75302-64-6
2-chloro-5-fluoropyridine-3-carboxamide

: 1361569-72-3
5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 °C

2.1: hydrazine hydrate / ethylene glycol / 4 h / Reflux

3.1: boron trifluoride diethyl etherate; isopentyl nitrite / tetrahydrofuran / 0.5 h / -10 - 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: bis(tri-n-butyltin); tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 60 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; bis(tri-n-butyltin); caesium carbonate; hydrazine hydrate; triethylamine; trifluoroacetic anhydride; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; dichloromethane; ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 1034667-22-5
5-fluoro-1H-pyrazolo[3,4-b]pyridine-3-amine

: 1361569-72-3
5-fluoro-1-(2-fluorobenzyl)-3-(7H-pyrrolo[2,3-d]pyrimidin-2-yl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate; isopentyl nitrite / tetrahydrofuran / 0.5 h / -10 - 0 °C

1.2: 0.5 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: bis(tri-n-butyltin); tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 60 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron trifluoride diethyl etherate; bis(tri-n-butyltin); caesium carbonate; isopentyl nitrite; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;