4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile

Base Information

• Chemical Name: 4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile
• CAS No.: 868612-72-0
• Molecular Formula: C₂₅H₁₈N₆O
• Molecular Weight: 418.458
• Mol file: 868612-72-0.mol

Synonyms:4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile

Chemical Property of 4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile

There total 2 articles about 4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

1-(6-methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione 1-oxime (356560-77-5) + 2-(4-cyanophenyl)acetaldehyde (76113-58-1) → 4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile (868612-72-0)

Guidance literature:

With ammonium acetate; In methanol; tert-butyl methyl ether; at 20 ℃;

Reference yield:

2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone (356560-90-2) → 4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile (868612-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; hydrogenchloride; water / 1 h / 20 °C

2: ammonium acetate / methanol; tert-butyl methyl ether / 20 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; water; sodium nitrite; In methanol; tert-butyl methyl ether;

DOI:10.1080/14756366.2020.1734799

Reference yield:

4-((1-hydroxy-5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl)methyl)benzonitrile (868612-72-0) → C25H20N6O2

Guidance literature:

With sodium hydroxide; dihydrogen peroxide; In ethanol; dimethyl sulfoxide; at 20 - 60 ℃;

upstream raw materials:

1-(6-methylpyridin-2-yl)-2-(quinoxalin-6-yl)ethane-1,2-dione 1-oxime

2-(4-cyanophenyl)acetaldehyde

2-(6-methylpyridin-2-yl)-1-(quinoxalin-6-yl)ethanone