[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone

Base Information

• Chemical Name: [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone
• CAS No.: 1373536-42-5
• Molecular Formula: C₁₈H₂₀F₃N₃O
• Molecular Weight: 351.372
• Mol file: 1373536-42-5.mol

Synonyms:[3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone

Chemical Property of [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone

There total 4 articles about [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

5-fluoro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride (1255735-11-5) + 2-(3-methylbenzyl)pyrrolidine (383127-61-5) → [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone (1373536-42-5)

Guidance literature:

5-fluoro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride; 2-(3-methylbenzyl)pyrrolidine; With triethylamine; In tetrahydrofuran; at 20 - 70 ℃;

With hydrogenchloride; In water; ethyl acetate;

With potassium carbonate; In water; ethyl acetate;

Reference yield:

5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde (660845-30-7) → [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone (1373536-42-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide; dihydrogen peroxide / toluene; water / 37 - 50 °C

1.2: pH 2

2.1: thionyl chloride / 5 h / Reflux

3.1: potassium fluoride / sulfolane; toluene / 100 - 200 °C

4.1: sodium hydroxide; water / sulfolane; water / 20 °C

4.2: pH 2

5.1: thionyl chloride / 1.5 h / Reflux

6.1: triethylamine / tetrahydrofuran / 20 - 70 °C

With potassium fluoride; thionyl chloride; water; dihydrogen peroxide; triethylamine; sodium hydroxide; In tetrahydrofuran; sulfolane; water; toluene;

Reference yield:

5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (1202993-11-0) → [3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazol-4-yl][2-(3-methyl-benzyl)pyrrolidin-1-yl]methanone (1373536-42-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 5 h / Reflux

2.1: potassium fluoride / sulfolane; toluene / 100 - 200 °C

3.1: sodium hydroxide; water / sulfolane; water / 20 °C

3.2: pH 2

4.1: thionyl chloride / 1.5 h / Reflux

5.1: triethylamine / tetrahydrofuran / 20 - 70 °C

With potassium fluoride; thionyl chloride; water; triethylamine; sodium hydroxide; In tetrahydrofuran; sulfolane; water; toluene;

upstream raw materials:

5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbaldehyde

5-chloro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid

1?methyl?3?difluoromethyl?5?chloropyrazole?4?carbonyl chloride

5-fluoro-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carbonyl chloride