593-66-8Relevant articles and documents
Yamashita et al.
, p. 659,660,662 (1972)
Acyl iodides in organic synthesis: VI. Reactions with vinyl ethers
Voronkov,Trukhina,Vlasova
, p. 467 - 469 (2007/10/03)
Reactions of acetyl iodide with butyl vinyl ether, 1,2-divinyloxyethane, phenyl vinyl ether, 1,4-di-vinyloxybenzene, and divinyl ether were studied. Vinyl ethers derived from aliphatic alcohols (butyl vinyl ether and 1,2-divinyloxyethane) react with acetyl iodide in a way similar to ethyl vinyl ether, i.e., with cleavage of both O-Csp2 and Alk-O ether bonds. From butyl vinyl ether, a mixture of vinyl iodide, butyl acetate, vinyl acetate, and butyl iodide is formed, while 1,2-divinyloxyethane gives rise to vinyl iodide, vinyl acetate, and 2-iodoethyl acetate. The reaction of acetyl iodide with divinyl ether involves cleavage of only one O-Csp2 bond, yielding vinyl acetate and vinyl iodide. In the reactions of acetyl iodide with phenyl vinyl ether and 1,4-divinyloxybenzene, only the O-CVin bond is cleaved, whereas the O-CAr bond remains intact.
Novel angiogenesis inhibitors and pharmaceutical and cosmetic use thereof
-
, (2008/06/13)
The invention relates to novel 1-oxaspiro[2,5]octan-6-ol derivatives of general formula (1): and also to a method for preparing them, and to their use in pharmaceutical compositions for use in human or veterinary medicine, or in cosmetic compositions.