3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol

Base Information

• Chemical Name: 3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol
• CAS No.: 882512-72-3
• Molecular Formula: C₁₈H₂₄O₃
• Molecular Weight: 288.387
• Mol file: 882512-72-3.mol

Synonyms:3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol

Chemical Property of 3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol

There total 14 articles about 3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one (882512-66-5) + lithium acetylide-ethylenediamine complex (1216963-74-4) → 3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol (882512-72-3)

Guidance literature:

In tetrahydrofuran; for 2h; sonication;

DOI:10.1016/j.tet.2006.01.021

Reference yield:

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-ol (882512-68-7) → 3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol (882512-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 96 percent / PCC; silica gel / CH₂Cl₂ / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.67 h / 20 °C

2.2: tetrahydrofuran; various solvent(s) / 10 h / 20 °C

2.3: 91 percent / tetrahydrofuran; various solvent(s) / 0.5 h / 180 °C

3.1: 90 percent / tetrahydrofuran / 2 h / sonication

With silica gel; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2006.01.021

Reference yield:

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-one (882512-69-8) → 3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-en-1-yn-3-ol (882512-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.67 h / 20 °C

1.2: tetrahydrofuran; various solvent(s) / 10 h / 20 °C

1.3: 91 percent / tetrahydrofuran; various solvent(s) / 0.5 h / 180 °C

2.1: 90 percent / tetrahydrofuran / 2 h / sonication

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tet.2006.01.021

upstream raw materials:

1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylpent-4-en-1-one

lithium acetylide-ethylenediamine complex

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-one

1-(2,3-dimethoxy-5-methylphenyl)-2-methyl-propan-1-ol

Downstream raw materials:

1,2-dimethoxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)benzene

1,2-dihydroxy-5-methyl-3-(1',2',2'-trimethylcyclopentyl)benzene

ethyl 3-vinyl-3-(2,3-dimethoxy-5-methylphenyl)-4,4-dimethylhept-6-enoate

ethyl 2-[1-(2,3-dimethoxy-5-methylphenyl)-2,2-dimethylcyclopent-1-yl]acetate