5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

Base Information

Chemical Name:5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole
CAS No.:450835-47-9
Molecular Formula:C₁₉H₁₅ClIN₃O
Molecular Weight:463.705
Hs Code.:

Synonyms:5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

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Technology Process of 5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

There total 5 articles about 5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 371765-91-2
4-(hydroxy(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

: 343929-11-3
1-(bromomethyl)-4-chloro-2-iodobenzene

: 450835-47-9
5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

Guidance literature:: With silver(l) oxide; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm030434f

Reference yield:

: 33184-48-4
4-chloro-2-iodotoluene

: 450835-47-9
5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: 3.24 g / NBS; benzoyl peroxide / CCl₄ / 48 h / Heating

2: 70 percent / Ag₂O / CH₂Cl₂ / 12 h / 20 °C

With N-Bromosuccinimide; silver(l) oxide; dibenzoyl peroxide; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm030434f

Reference yield:

: 105-07-7
4-cyanobenzaldehyde

: 450835-47-9
5-[(4-chloro-2-iodobenzyloxy)-(4-cyanophenyl)methyl]-1-methyl-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: tetrahydrofuran; hexane / 3 h / -78 °C

2.1: 2.52 g / aq. HCl / tetrahydrofuran; hexane; methanol

3.1: 70 percent / Ag₂O / CH₂Cl₂ / 12 h / 20 °C

With hydrogenchloride; tert.-butyl lithium; silver(l) oxide; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jm030434f