4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide

Base Information

• Chemical Name: 4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide
• CAS No.: 1615693-83-8
• Molecular Formula: C₃₁H₄₁N₇O₉
• Molecular Weight: 655.708
• Mol file: 1615693-83-8.mol

Synonyms:4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide

Chemical Property of 4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide

There total 2 articles about 4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

O-2-tetrahydro-2H-pyranhydroxylamine (6723-30-4) + ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate (1615693-67-8) → 4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide (1615693-83-8)

Guidance literature:

O-2-tetrahydro-2H-pyranhydroxylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate; With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.ejmech.2014.04.083

Reference yield:

4,4'-diaminobenzanilide (785-30-8) → 4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide (1615693-83-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere; Cooling with ice

With N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/j.ejmech.2014.04.083

Reference yield:

4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)-N-(4-(3-ethoxycarbonyl-2-((tetrahydro-2H-pyran-2-yl)oxy)guanidino)phenyl)benzamide (1615693-83-8) → 4-(2-hydroxyguanidino)-N-(4-(2-hydroxyguanidino)phenyl)benzamide dihydrochloride

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / methanol; water / 80 °C / Sealed tube

2: hydrogenchloride / methanol; 1,4-dioxane / 12 h / 20 °C

With hydrogenchloride; potassium hydroxide; In 1,4-dioxane; methanol; water;

DOI:10.1016/j.ejmech.2014.04.083

upstream raw materials:

4,4'-diaminobenzanilide

O-2-tetrahydro-2H-pyranhydroxylamine

ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate