ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate

Base Information

• Chemical Name: ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate
• CAS No.: 1615693-67-8
• Molecular Formula: C₂₁H₂₃N₅O₅S₂
• Molecular Weight: 489.576
• Mol file: 1615693-67-8.mol

Synonyms:ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate

Chemical Property of ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate

There total 1 articles about ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4,4'-diaminobenzanilide (785-30-8) + Ethoxycarbonyl isothiocyanate (16182-04-0) → ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate (1615693-67-8)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.04.083

Reference yield: 81.0%

ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate (1615693-67-8) + ethanamine hydrochloride (557-66-4) → 4-(2-ethyl-3-ethoxycarbonylguanidino)-N-(4-(2-ethyl-3-ethoxycarbonylguanidino)phenyl)benzamide (1615693-73-6)

Guidance literature:

ethanamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate; With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.ejmech.2014.04.083

Reference yield: 80.0%

N-benzyloxyamine (622-33-3) + ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate (1615693-67-8) → 4-(2-benzyloxy-3-ethoxycarbonylguanidino)-N-(4-(2-benzyloxy-3-ethoxycarbonylguanidino)phenyl)benzamide (1615693-81-6)

Guidance literature:

N-benzyloxyamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

ethyl N-((4-((4-((((ethoxycarbonyl)amino)methanethioyl)amino)phenyl)carbamoyl)phenyl)carbamothioyl)carbamate; With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere; Cooling with ice;

DOI:10.1016/j.ejmech.2014.04.083

upstream raw materials:

4,4'-diaminobenzanilide

Ethoxycarbonyl isothiocyanate

Downstream raw materials:

4-(2-methylguanidino)-N-(4-(2-methylguanidino)phenyl)benzamide

4-(2-ethylguanidino)-N-(4-(2-ethylguanidino)phenyl)benzamide

4-(2-isopropylguanidino)-N-(4-(2-isopropylguanidino)phenyl)benzamide

4-(2-methoxyguanidino)-N-(4-(2-methoxyguanidino)phenyl)benzamide