2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline

Base Information

Chemical Name:2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline
CAS No.:213541-01-6
Molecular Formula:C₂₆H₂₁F₂NO₃
Molecular Weight:433.454
Hs Code.:

Synonyms:2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline

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Chemical Property of 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline

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Technology Process of 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline

There total 5 articles about 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 406219-68-9
2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

: 213541-01-6
2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline

Guidance literature:: 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid; With thionyl chloride; N,N-dimethyl-formamide; In toluene; at 55 ℃; for 2h;

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 1.5h;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 213541-01-6
2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2.1: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

3.1: SOCl₂ / toluene / 3 h / 50 °C

3.2: 99 percent / toluene / 3 h / 0 °C

4.1: SOCl₂; DMF / toluene / 2 h / 55 °C

4.2: 75 percent / NaBH₄ / tetrahydrofuran / 1.5 h / 20 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Friedel-Crafts reaction / 2.1: Pfitzinger reaction;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 321-60-8
2-fluorobiphenyl

: 213541-01-6
2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-4-hydroxymethyl-6-fluoroquinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2.1: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

3.1: SOCl₂ / toluene / 3 h / 50 °C

3.2: 99 percent / toluene / 3 h / 0 °C

4.1: SOCl₂; DMF / toluene / 2 h / 55 °C

4.2: 75 percent / NaBH₄ / tetrahydrofuran / 1.5 h / 20 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Friedel-Crafts reaction / 2.1: Pfitzinger reaction;
DOI:10.1016/S0968-0896(01)00238-3