2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

Base Information

Chemical Name:2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid
CAS No.:406219-68-9
Molecular Formula:C₂₆H₁₉F₂NO₄
Molecular Weight:447.438
Hs Code.:

Synonyms:2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

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Chemical Property of 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

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Technology Process of 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

There total 4 articles about 2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 67-56-1
methanol

: 213541-12-9
2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid

: 406219-68-9
2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

Guidance literature:: 2-[4-(2-fluorophenyl)phenyl]-3-(2-carboxyethyl)-6-fluoroquinoline-4-carboxylic acid; With thionyl chloride; In toluene; at 50 ℃; for 3h;

methanol; In toluene; at 0 ℃; for 3h;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 406219-68-9
2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2.1: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

3.1: SOCl₂ / toluene / 3 h / 50 °C

3.2: 99 percent / toluene / 3 h / 0 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Friedel-Crafts reaction / 2.1: Pfitzinger reaction;
DOI:10.1016/S0968-0896(01)00238-3

Reference yield:

: 321-60-8
2-fluorobiphenyl

: 406219-68-9
2-[4-(2-fluorophenyl)phenyl]-3-[(2-methoxycarbonyl)ethyl]-6-fluoroquinoline-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 75 percent / AlCl₃ / CH₂Cl₂ / 8 h / 5 °C

2.1: 89 percent / KOH / ethanol; dioxane; H₂O / 13 h / 55 °C

3.1: SOCl₂ / toluene / 3 h / 50 °C

3.2: 99 percent / toluene / 3 h / 0 °C

With potassium hydroxide; aluminium trichloride; thionyl chloride; In 1,4-dioxane; ethanol; dichloromethane; water; toluene; 1.1: Friedel-Crafts reaction / 2.1: Pfitzinger reaction;
DOI:10.1016/S0968-0896(01)00238-3