Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Base Information

Chemical Name:Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate
CAS No.:1256570-45-2
Molecular Formula:C₂₀H₂₅F₃N₂O₄
Molecular Weight:414.425
Hs Code.:

Synonyms:Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

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Chemical Property of Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Chemical Property:

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Technology Process of Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

There total 4 articles about Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15159-40-7
4-morpholinocarbonyl chloride

: 1256570-43-0
methyl {5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

: 1256570-45-2
Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 118650-08-1
(5-bromo-pyridin-3-yl)-acetic acid methyl ester

: 1256570-45-2
Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water; dimethoxyethane-1,2 / 20 - 85 °C / Inert atmosphere

2: hydrogen / palladium on activated charcoal / ethanol; water / 60 °C / 37503.8 Torr / Inert atmosphere

3: dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogen; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In dimethoxyethane-1,2; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 39891-12-8
5-bromo-3-pyridineacetic acid

: 1256570-45-2
Methyl {1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidin-3-yl}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 2 h / Reflux

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water; dimethoxyethane-1,2 / 20 - 85 °C / Inert atmosphere

3: hydrogen / palladium on activated charcoal / ethanol; water / 60 °C / 37503.8 Torr / Inert atmosphere

4: dichloromethane / 0 - 20 °C / Inert atmosphere

With hydrogen; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; dimethoxyethane-1,2; ethanol; dichloromethane; water; N,N-dimethyl-formamide;