Technology Process of N-(3-{[2-(acetylamino)imidazo[1,2-a]pyridin-6-yl]oxy}phenyl)-3-methylpyridine-2-carboxamide
There total 10 articles about N-(3-{[2-(acetylamino)imidazo[1,2-a]pyridin-6-yl]oxy}phenyl)-3-methylpyridine-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide; acetyl chloride;
In
N,N-dimethyl acetamide;
at 20 ℃;
for 3h;
With
methanol; water; sodium hydrogencarbonate;
In
tetrahydrofuran; N,N-dimethyl acetamide;
at 60 ℃;
for 68h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: caesium carbonate / N,N-dimethyl-formamide / 15 h / 50 °C
2.1: hydrogen / palladium on activated charcoal / methanol / 12 h / 20 °C
3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
3.2: 13 h / 20 °C
4.1: dimethyl sulfoxide / 12 h / 20 °C
5.1: pyridine / 2 h / 80 °C
6.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
6.2: 71 h / 20 °C
7.1: trifluoroacetic anhydride / tetrahydrofuran / 2 h / 20 °C
7.2: 19 h / 20 °C
8.1: N,N-dimethyl acetamide / 3 h / 20 °C
8.2: 68 h / 60 °C
With
pyridine; oxalyl dichloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
palladium on activated charcoal; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
1.2: 13 h / 20 °C
2.1: dimethyl sulfoxide / 12 h / 20 °C
3.1: pyridine / 2 h / 80 °C
4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C
4.2: 71 h / 20 °C
5.1: trifluoroacetic anhydride / tetrahydrofuran / 2 h / 20 °C
5.2: 19 h / 20 °C
6.1: N,N-dimethyl acetamide / 3 h / 20 °C
6.2: 68 h / 60 °C
With
pyridine; oxalyl dichloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride;
N,N-dimethyl-formamide;
In
tetrahydrofuran; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide;
![N-{3-[(2-aminoimidazo[1,2-a]pyridin-6-yl)oxy]phenyl}-3-methylpyridine-2-carboxamide](/Databaselist/images/loading.webp)
