Tetrahydro-4-methoxy-4-(3-methylphenyl)-2H-pyran

Base Information

Chemical Name:Tetrahydro-4-methoxy-4-(3-methylphenyl)-2H-pyran
CAS No.:145127-35-1
Molecular Formula:C₁₃H₁₈O₂
Molecular Weight:206.285
Hs Code.:
DSSTox Substance ID:DTXSID001239781

Synonyms:SCHEMBL12672077;DTXSID001239781;145127-35-1;Tetrahydro-4-methoxy-4-(3-methylphenyl)-2H-pyran

Suppliers and Price of Tetrahydro-4-methoxy-4-(3-methylphenyl)-2H-pyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Tetrahydro-4-methoxy-4-(3-methylphenyl)-2H-pyran

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:206.130679813
Heavy Atom Count:15
Complexity:197

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=CC=C1)C2(CCOCC2)OC

Technology Process of Tetrahydro-4-methoxy-4-(3-methylphenyl)-2H-pyran

There total 3 articles about Tetrahydro-4-methoxy-4-(3-methylphenyl)-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 145127-34-0
3-(4-hydroxytetrahydro-2H-pyran-4-yl)toluene

: 74-88-4
methyl iodide

: 145127-35-1
3-(4-methoxytetrahydro-2H-pyran-4-yl)toluene

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2011.01.043

Reference yield:

: 591-17-3
meta-bromotoluene

: 145127-35-1
3-(4-methoxytetrahydro-2H-pyran-4-yl)toluene

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 45 min, 2.) THF, hexane, RT, 1.5 h

2: 53 percent / NaH / dimethylformamide / 15 h / Ambient temperature

With n-butyllithium; sodium hydride; In N,N-dimethyl-formamide;
DOI:10.1021/jm00030a010

Reference yield:

: 591-17-3
meta-bromotoluene

: 145127-35-1
3-(4-methoxytetrahydro-2H-pyran-4-yl)toluene

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium / tetrahydrofuran / Reflux

1.2: 1 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C

With sodium hydride; magnesium; In tetrahydrofuran; mineral oil;
DOI:10.1016/j.bmc.2011.01.043