N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide

Base Information

Chemical Name:N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide
CAS No.:1262786-60-6
Molecular Formula:C₁₇H₂₁NO₃S
Molecular Weight:319.425
Hs Code.:

Synonyms:N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide

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Chemical Property of N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide

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Technology Process of N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide

There total 7 articles about N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1262786-59-3
N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

: 1262786-60-6
N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 18h;

Reference yield:

: 5292-53-5
diethyl benzalmalonate

: 1262786-60-6
N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / ethanol / 18 h / 70 °C

2.1: hydrogenchloride; hydrogen / palladium-on-charcoal / ethanol; water / 18 h / 4137.29 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

4.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

4.2: 0.17 h / 20 °C / pH 8 / aqueous pH 8 buffer

5.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran; Pionier 2076 / 1 h / 20 °C / Inert atmosphere

6.2: 2.5 h / 20 °C / Inert atmosphere

7.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 18 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium borohydride; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; dmap; palladium-on-charcoal; In tetrahydrofuran; ethanol; dichloromethane; Pionier 2076; water;

Reference yield:

: 14025-83-3
3-cyano-3-phenylpropanoic acid ethyl ester

: 1262786-60-6
N-(4-hydroxy-2-phenylbutyl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; hydrogen / palladium-on-charcoal / ethanol; water / 18 h / 4137.29 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

3.2: 0.17 h / 20 °C / pH 8 / aqueous pH 8 buffer

4.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; Pionier 2076 / 1 h / 20 °C / Inert atmosphere

5.2: 2.5 h / 20 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 18 h / 20 °C

With 1H-imidazole; hydrogenchloride; lithium borohydride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; dmap; palladium-on-charcoal; In tetrahydrofuran; ethanol; dichloromethane; Pionier 2076; water;