N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

Base Information

Chemical Name:N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide
CAS No.:1262786-59-3
Molecular Formula:C₂₃H₃₅NO₃SSi
Molecular Weight:433.687
Hs Code.:

Synonyms:N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

There total 6 articles about N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1262786-58-2
N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)benzenesulfonamide

: 74-88-4
methyl iodide

: 1262786-59-3
N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

Guidance literature:: N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)benzenesulfonamide; With sodium hydride; In tetrahydrofuran; Pionier 2076; at 20 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; Pionier 2076; at 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

: 14025-83-3
3-cyano-3-phenylpropanoic acid ethyl ester

: 1262786-59-3
N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; hydrogen / palladium-on-charcoal / ethanol; water / 18 h / 4137.29 Torr

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

3.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

3.2: 0.17 h / 20 °C / pH 8 / aqueous pH 8 buffer

4.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; Pionier 2076 / 1 h / 20 °C / Inert atmosphere

5.2: 2.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; lithium borohydride; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; dmap; palladium-on-charcoal; In tetrahydrofuran; ethanol; dichloromethane; Pionier 2076; water;

Reference yield:

: 5292-53-5
diethyl benzalmalonate

: 1262786-59-3
N-(4-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-phenylbutyl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: water / ethanol / 18 h / 70 °C

2.1: hydrogenchloride; hydrogen / palladium-on-charcoal / ethanol; water / 18 h / 4137.29 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C / Inert atmosphere

4.1: lithium borohydride / tetrahydrofuran / 2 h / 65 °C / Inert atmosphere

4.2: 0.17 h / 20 °C / pH 8 / aqueous pH 8 buffer

5.1: 1H-imidazole / dmap / dichloromethane / 0.33 h / 20 °C / Inert atmosphere

6.1: sodium hydride / tetrahydrofuran; Pionier 2076 / 1 h / 20 °C / Inert atmosphere

6.2: 2.5 h / 20 °C / Inert atmosphere

With 1H-imidazole; hydrogenchloride; lithium borohydride; water; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; dmap; palladium-on-charcoal; In tetrahydrofuran; ethanol; dichloromethane; Pionier 2076; water;