N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride

Base Information

Chemical Name:N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride
CAS No.:1386984-19-5
Molecular Formula:C₂₀H₁₆ClF₄N₅O₂*ClH
Molecular Weight:506.287
Hs Code.:

Synonyms:N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride

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Chemical Property of N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride

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Technology Process of N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride

There total 26 articles about N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1386985-76-7
((2R,5R)-5-{5-[(3-chloro-5-cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester

: 1386984-19-5
N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride

Guidance literature:: ((2R,5R)-5-{5-[(3-chloro-5-cyano-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 2h;

With potassium carbonate; In dichloromethane; water; Cooling;

With hydrogenchloride; In diethyl ether; dichloromethane;

Reference yield:

: 1262859-67-5
(2R,5R)-5-(2-fluorophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

: 1386984-19-5
N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium nitrate; sulfuric acid / 2 h / 25 °C / Cooling with ice

1.2: Cooling

2.1: triethylamine / acetonitrile / 16 h / 25 °C

3.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol; tetrahydrofuran / 4 h / 50 °C

4.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 25 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

5.2: Cooling

With 1-hydroxy-7-aza-benzotriazole; sulfuric acid; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

Reference yield:

: 1262859-69-7
tert-butyl ((2R,5R)-5-(2-fluoro-5-nitrophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-yl)carbamate

: 1386984-19-5
N-(3-((3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl)-4-fluorophenyl)-3-chloro-5-cyanopicolinamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol; tetrahydrofuran / 4 h / 50 °C

2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 16 h / 25 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 25 °C

3.2: Cooling

With 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;