(R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine

Base Information

• Chemical Name: (R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine
• CAS No.: 1262859-62-0
• Molecular Formula: C₁₅H₁₂BrFN₂O₄S
• Molecular Weight: 415.24

Synonyms:(R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine

Chemical Property of (R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine

Chemical Property:

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Technology Process of (R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine

There total 14 articles about (R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(S)-2-(5-Bromo-2-fluoro-phenyl)-2-hydroxy-propyl]-2-nitro-benzenesulfonamide (1262859-61-9) → (R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine (1262859-62-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; at 0 - 25 ℃; for 24h;

Reference yield:

N-[(S)-2-(5-Bromo-2-fluoro-phenyl)-2-hydroxy-propyl]-2-nitro-benzenesulfonamide (1262859-61-9) + diethylazodicarboxylate (1972-28-7,218603-74-8) → (R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine (1262859-62-0)

Guidance literature:

With triphenylphosphine; In dichloromethane;

Reference yield:

(S)-2-(5-bromo-2-fluoro-phenyl)-2-methyl-oxirane (1262859-57-3) → (R)-2-(5-bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine (1262859-62-0)

Guidance literature:

Multi-step reaction with 4 steps

1: ammonium chloride; sodium azide / ethanol

2: NaOH; LiAlH₄ / water; tetrahydrofuran

3: sodium hydroxide / tetrahydrofuran

4: triphenylphosphine / dichloromethane

With sodium hydroxide; NaOH; sodium azide; LiAlH₄; ammonium chloride; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; water;

upstream raw materials:

N-[(S)-2-(5-Bromo-2-fluoro-phenyl)-2-hydroxy-propyl]-2-nitro-benzenesulfonamide

diethylazodicarboxylate

(S)-2-(5-bromo-2-fluoro-phenyl)-2-methyl-oxirane

(S)-1-azido-2-(5-bromo-2-fluoro-phenyl)-propan-2-ol

Downstream raw materials:

(R)-2-[(R)-2-(5-bromo-2-fluoro-phenyl)-2-(2-nitro-benzenesulfonylamino)-propoxy]-3,3,3-trifluoro-2-methyl-propionic acid ethyl ester

N-[(R)-1-(5-bromo-2-fluoro-phenyl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methyl-ethoxy)-1-methyl-ethyl]-2-nitro-benzenesulfonamide

tert-butyl ((2R,5R)-5-(2-fluoro-5-nitrophenyl)-2,5-dimethyl-2-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-yl)carbamate

[(2R,5R)-5-(5-amino-2-fluoro-phenyl)-2,5-dimethyl-2-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

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