methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate

Base Information

• Chemical Name: methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate
• CAS No.: 959939-54-9
• Molecular Formula: C₁₈H₂₄N₄O₇
• Molecular Weight: 408.411
• Mol file: 959939-54-9.mol

Synonyms:methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate

Chemical Property of methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate

There total 12 articles about methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl trans-3-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]-cyclohexyl]oxypropanoate (959939-53-8) → methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate (959939-54-9)

Guidance literature:

With hydrazine; In ethanol; at 60 ℃; for 1h;

Reference yield:

4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane (680596-79-6) → methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate (959939-54-9)

Guidance literature:

Multi-step reaction with 11 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide; water / 24 h / 80 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl acetamide / 16 h / 60 °C

4.1: water; trifluoroacetic acid / 72 h / 20 °C

5.1: sodium tetrahydroborate / ethanol; acetonitrile / 1 h / 20 °C

5.2: 0.25 h / 20 °C

6.1: sodium hydroxide; water; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 16 h / 20 °C

7.1: hydrogenchloride / water / 4 h / 70 °C

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

9.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

10.1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 2.52 h / 0 - 20 °C

11.1: hydrazine / ethanol / 1 h / 60 °C

With ammonium nitrate; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; water; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

4-(1,4-dioxaspiro[4,5]dec-8-yl)benzenamine (389602-90-8) → methyl trans-3-[4-[4-[(hydrazinecarbonylformyl)amino]-3-nitro-phenyl]cyclohexyl]oxypropanoate (959939-54-9)

Guidance literature:

Multi-step reaction with 9 steps

1.1: potassium carbonate / N,N-dimethyl acetamide / 16 h / 60 °C

2.1: water; trifluoroacetic acid / 72 h / 20 °C

3.1: sodium tetrahydroborate / ethanol; acetonitrile / 1 h / 20 °C

3.2: 0.25 h / 20 °C

4.1: sodium hydroxide; water; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 16 h / 20 °C

5.1: hydrogenchloride / water / 4 h / 70 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

8.1: ammonium nitrate; trifluoroacetic anhydride / dichloromethane / 2.52 h / 0 - 20 °C

9.1: hydrazine / ethanol / 1 h / 60 °C

With ammonium nitrate; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; water; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trifluoroacetic anhydride; hydrazine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

upstream raw materials:

methyl trans-3-[4-[4-[(methoxycarbonylformyl)amino]-3-nitro-phenyl]-cyclohexyl]oxypropanoate

4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

4-(1,4-dioxaspiro[4,5]dec-8-yl)benzenamine

methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate