methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate

Base Information

Chemical Name:methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate
CAS No.:959939-51-6
Molecular Formula:C₁₆H₂₃NO₃
Molecular Weight:277.364
Hs Code.:

Synonyms:methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate

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Chemical Property of methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate

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Technology Process of methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate

There total 9 articles about methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 959939-50-5
methyl trans-3-[4-[4-(dibenzylamino)phenyl]cyclohexyl]oxypropanoate

: 959939-51-6
methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 680596-79-6
4,4,5,5-tetramethyl-2-(1,4-dioxaspiro[4.5]dec-7-en-8-yl)-1,3,2-dioxaborolane

: 959939-51-6
methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl acetamide; water / 24 h / 80 °C

2.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl acetamide / 16 h / 60 °C

4.1: water; trifluoroacetic acid / 72 h / 20 °C

5.1: sodium tetrahydroborate / ethanol; acetonitrile / 1 h / 20 °C

5.2: 0.25 h / 20 °C

6.1: sodium hydroxide; water; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 16 h / 20 °C

7.1: hydrogenchloride / water / 4 h / 70 °C

8.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; water; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

: 389602-90-8
4-(1,4-dioxaspiro[4,5]dec-8-yl)benzenamine

: 959939-51-6
methyl trans-3-[4-(4-aminophenyl)cyclohexyl]oxypropanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl acetamide / 16 h / 60 °C

2.1: water; trifluoroacetic acid / 72 h / 20 °C

3.1: sodium tetrahydroborate / ethanol; acetonitrile / 1 h / 20 °C

3.2: 0.25 h / 20 °C

4.1: sodium hydroxide; water; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 16 h / 20 °C

5.1: hydrogenchloride / water / 4 h / 70 °C

6.1: hydrogen / palladium 10% on activated carbon / tetrahydrofuran / 16 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; water; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl acetamide; water; acetonitrile;