4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide

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Chemical Name:4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide
CAS No.:1367874-96-1
Molecular Formula:C₃₇H₃₇N₅O₂
Molecular Weight:583.733
Hs Code.:

Synonyms:4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide

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Chemical Property of 4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide

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Technology Process of 4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide

There total 11 articles about 4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367874-95-0
4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-1H-pyrrole-2-carboxyilic acid

: 593-51-1
methylamine hydrochloride

: 1367874-96-1
4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 25 ℃;

Reference yield:

: 134031-24-6
2,4-dichloro-3-pyridine Carboxaldehyde

: 1367874-96-1
4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

2.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 19 h / 20 °C

4.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

4.2: 4 h / Reflux

5.1: potassium acetate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / tetrahydrofuran; acetonitrile / 0.67 h / 145 °C / Inert atmosphere; Microwave irradiation

6.1: lithium hydroxide / tetrahydrofuran / 12 h / Reflux

6.2: 20 °C / pH 7

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 25 °C

With iodine; potassium acetate; sodium hydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; lithium hydroxide; di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1367874-96-1
4-(4-isopropoxy-1-trityl-1H-pyrzolo[4,3-c]pyridine-3-yl)-1-isopropyl-N-methyl-1H-pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3.5 h / -78 - 0 °C

1.2: 1.5 h / -78 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

3.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 19 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C

5.2: 4 h / Reflux

6.1: potassium acetate / di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium / tetrahydrofuran; acetonitrile / 0.67 h / 145 °C / Inert atmosphere; Microwave irradiation

7.1: lithium hydroxide / tetrahydrofuran / 12 h / Reflux

7.2: 20 °C / pH 7

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 25 °C

With n-butyllithium; iodine; potassium acetate; sodium hydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; lithium hydroxide; di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;