2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide

Base Information

Chemical Name:2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide
CAS No.:1309765-44-3
Molecular Formula:C₂₁H₂₉N₃O₂
Molecular Weight:355.48
Hs Code.:

Synonyms:2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide

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Chemical Property of 2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide

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Technology Process of 2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide

There total 3 articles about 2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1309765-93-2
[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-acetic acid

: 75-04-7,85404-22-4
ethylamine

: 1309765-44-3
2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

Reference yield:

: 1255644-43-9
4-(2-methoxy-ethyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 1309765-44-3
2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylaluminum chloride / ethyl acetate; toluene; hexane; methanol / 15 h / 115 °C

1.2: pH 2

1.3: pH 8

2.1: triethylamine / dichloromethane / 16 h / 20 °C

3.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

With dimethylaluminum chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 1309765-44-3
2-[2-(4-Cyclopropyl-phenyl)-1-oxo-2,8-diaza-spiro[4.5]dec-8-yl]-N-ethyl-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -5 °C

1.2: -5 - 20 °C

2.1: dimethylaluminum chloride / ethyl acetate; toluene; hexane; methanol / 15 h / 115 °C

2.2: pH 2

2.3: pH 8

3.1: triethylamine / dichloromethane / 16 h / 20 °C

4.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C

With dimethylaluminum chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;