2,5-Di(2-naphthyl)-1,3,4-oxadiazole

Base Information

• Chemical Name: 2,5-Di(2-naphthyl)-1,3,4-oxadiazole
• CAS No.: 802-51-7
• Molecular Formula: C22H14N2O
• Molecular Weight: 322.366
• European Community (EC) Number: 212-352-4
• NSC Number: 90481
• DSSTox Substance ID: DTXSID70230150
• Nikkaji Number: J193.184I
• Wikidata: Q83110559
• Mol file: 802-51-7.mol

Synonyms:2,5-Di(2-naphthyl)-1,3,4-oxadiazole;802-51-7;EINECS 212-352-4;NSC90481;SCHEMBL9195816;C22H14N2O;DTXSID70230150;NSC 90481;NSC-90481;2,5-di-2-naphthyl-1,3,4-oxadiazole;2,5-Bis(2-naphthyl)-1,3,4-oxadiazole;2,5-Di-(2-naphthyl)-1,3,4-oxadiazol

Chemical Property of 2,5-Di(2-naphthyl)-1,3,4-oxadiazole

Chemical Property:

• Vapor Pressure: 7.55E-12mmHg at 25°C
• Boiling Point: 556.4°C at 760 mmHg
• Flash Point: 293.1°C
• Density: 1.251g/cm³
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 322.110613074
• Heavy Atom Count: 25
• Complexity: 415

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C=CC2=C1)C3=NN=C(O3)C4=CC5=CC=CC=C5C=C4

Technology Process of 2,5-Di(2-naphthyl)-1,3,4-oxadiazole

There total 7 articles about 2,5-Di(2-naphthyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C26H22N4O4 (132500-91-5) → succinic acid (110-15-6) + 2,5-bis(2-naphthyl)-1,3,4-oxadiazole (802-51-7)

Guidance literature:

With trichlorophosphate; In acetonitrile; for 2h; Heating;

Reference yield: 50.0%

2-naphthohydrazide (39627-84-4) → 2,5-bis(2-naphthyl)-1,3,4-oxadiazole (802-51-7)

Guidance literature:

With PPA; at 180 ℃;

DOI:10.3987/COM-06-S(K)4

Reference yield:

methyl naphthalene-2-carboxylate (2459-25-8) → 2,5-bis(2-naphthyl)-1,3,4-oxadiazole (802-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine monohydrate / methanol

2: 50 percent / polyphosphoric acid / 180 °C

With PPA; hydrazine hydrate; In methanol;

DOI:10.3987/COM-06-S(K)4

upstream raw materials:

C₂₆H₂₂N₄O₄

2-naphthohydrazide

methyl naphthalene-2-carboxylate

naphthalene-2-carboxylate

Downstream raw materials:

3-methyl-2,5-di-naphthalen-2-yl-[1,3,4]oxadiazolium; toluene-4-sulfonate