(S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one

Base Information

Chemical Name:(S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one
CAS No.:197968-27-7
Molecular Formula:C₂₇H₃₆O₄Si
Molecular Weight:452.666
Hs Code.:

Synonyms:(S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one

Chemical Property:

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Technology Process of (S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one

There total 8 articles about (S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₀H₇₄O₈Si₂

: 197968-27-7
(S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile;
DOI:10.1021/ja953781q

Reference yield:

: 18922-04-8
6-iodohex-1-ene

: 197968-27-7
(S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 72 percent

2: 62 percent / AD-mix-β

3: 1.) CH(OME)3, PPTS, 2.) AcBr, 3.) K₂CO₃

4: BF₃*Et₂O

5: DMAP

6: PPTS / ethanol

7: 1.) Red-Al, 2.) I₂, 3.) (Ph₃P)2PdCl₂, NH₂NH₂, K₂CO₃

8: CAN / H₂O; acetonitrile

With dmap; bis-triphenylphosphine-palladium(II) chloride; ammonium cerium(IV) nitrate; Acetyl bromide; AD-mix-β; boron trifluoride diethyl etherate; iodine; pyridinium p-toluenesulfonate; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; hydrazine; trimethyl orthoformate; In ethanol; water; acetonitrile;
DOI:10.1021/ja953781q

Reference yield:

: 173427-90-2
1,4-di-(5-hexynyloxy)benzene

: 197968-27-7
(S)-3-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-hexyl]-5-methyl-5H-furan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 62 percent / AD-mix-β

2: 1.) CH(OME)3, PPTS, 2.) AcBr, 3.) K₂CO₃

3: BF₃*Et₂O

4: DMAP

5: PPTS / ethanol

6: 1.) Red-Al, 2.) I₂, 3.) (Ph₃P)2PdCl₂, NH₂NH₂, K₂CO₃

7: CAN / H₂O; acetonitrile

With dmap; bis-triphenylphosphine-palladium(II) chloride; ammonium cerium(IV) nitrate; Acetyl bromide; AD-mix-β; boron trifluoride diethyl etherate; iodine; pyridinium p-toluenesulfonate; potassium carbonate; sodium bis(2-methoxyethoxy)aluminium dihydride; hydrazine; trimethyl orthoformate; In ethanol; water; acetonitrile;
DOI:10.1021/ja953781q