9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine

Base Information

Chemical Name:9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine
CAS No.:1401447-74-2
Molecular Formula:C₁₀H₆ClN₃
Molecular Weight:203.631
Hs Code.:

Synonyms:9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine

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Chemical Property of 9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine

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Technology Process of 9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine

There total 1 articles about 9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 55052-28-3
4-chloro-7-azaindole

: 1401447-74-2
9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

2.1: trifluoroacetic anhydride; tetramethylammonium nitrate / dichloromethane / 20.5 h / -5 - 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / Inert atmosphere; Reflux

4.1: hydrogenchloride; water / acetone / 2 h / Reflux

5.1: toluene / 15 h / 85 °C

5.2: 2 h

5.3: 1 h / Reflux

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / Reflux

7.1: trichlorophosphate / chlorobenzene / 100 °C

With hydrogenchloride; dmap; lithium hydroxide monohydrate; water; tetramethylammonium nitrate; triethylamine; trifluoroacetic anhydride; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; chlorobenzene; acetone; toluene;

Reference yield:

: 1401447-74-2
9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine

: 1401448-23-4
[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 130 °C / Sealed tube; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran;

Reference yield:

: 1401447-74-2
9-chloro-3H-pyrrolo[3,2-f][1,7]naphthyridine

: 1401448-24-5
S-[[1-[3-(p-tolylsulfonyl)pyrrolo[3,2-f][1,7]naphthyridin-9-yl]-4-piperidyl]methyl]ethanethioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 130 °C / Sealed tube; Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C

4.1: dimethyl sulfoxide / 40 - 44 °C / Inert atmosphere

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide;