N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

Base Information

Chemical Name:N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide
CAS No.:1394431-38-9
Molecular Formula:C₂₇H₂₁ClN₂O₄S₂
Molecular Weight:537.06
Hs Code.:

Synonyms:N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

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Chemical Property of N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

Chemical Property:

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Technology Process of N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

There total 8 articles about N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 249292-39-5
6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonyl chloride

: 712-76-5
N-(4-phenyl)benzylamine

: 1394431-38-9
N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

Guidance literature:: In dichloromethane; Cooling with ice;
DOI:10.1016/j.bmcl.2016.08.018

Reference yield:

: 1394431-37-8
lithium 6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfinate

: 1394431-38-9
N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-chloro-succinimide / dichloromethane / 2 h / 5 °C

2: dichloromethane / Cooling with ice

With N-chloro-succinimide; In dichloromethane;
DOI:10.1016/j.bmcl.2016.08.018

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1394431-38-9
N-(biphenyl-4-ylmethyl)-6-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / 20 h / Reflux

2.1: sodium hydroxide / ethanol / 40 °C

2.2: 0.42 h / 250 °C / Microwave irradiation

3.1: sodium hydride / N,N-dimethyl-formamide / 18 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran / 0.5 h / -70 °C / Inert atmosphere

4.2: 2.25 h / -70 - 20 °C / Inert atmosphere

5.1: N-chloro-succinimide / dichloromethane / 2 h / 5 °C

6.1: dichloromethane / Cooling with ice

With N-chloro-succinimide; n-butyllithium; sodium hydride; toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2016.08.018