β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid

Base Information

• Chemical Name: β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid
• CAS No.: 69022-62-4
• Molecular Formula: C₁₀H₁₀ClNO₄
• Molecular Weight: 243.647
• Mol file: 69022-62-4.mol

Synonyms:β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid

Chemical Property of β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid

There total 1 articles about β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-o-tolylamine (603-83-8) + acrylic acid (79-10-7) → β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid (69022-62-4)

Guidance literature:

With sodium nitrite; Yield given. Multistep reaction; 1) acetone, 12N HCl, 0-5 deg C, 45 min., 2) acetone, H₂O, CuCl, 35 deg C, 65 min.;

DOI:10.1021/jo01299a028

Reference yield: 79.0%

β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid (69022-62-4) → (E)-3-(2-methyl-3-nitrophenyl)propenoic acid (73323-63-4)

Guidance literature:

With potassium hydroxide; In methanol; for 1h; Heating;

DOI:10.1021/jo01299a028

Reference yield:

β-(2-methyl-3-nitrophenyl)-α-chloropropionic acid (69022-62-4) → 3-acetamido-2-methylcinnamic acid (73323-29-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / KOH / methanol / 1 h / Heating

2: 1) H₂ / 1) raney nickel / 1) RT, 2) reflux, 2h

With potassium hydroxide; hydrogen; nickel; In methanol;

DOI:10.1021/jo01299a028

upstream raw materials:

3-nitro-o-tolylamine

acrylic acid

Downstream raw materials:

(E)-3-(2-methyl-3-nitrophenyl)propenoic acid

3-acetamido-2-methylcinnamic acid