(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

Base Information

Chemical Name:(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine
CAS No.:1218935-61-5
Molecular Formula:C₁₆H₁₃F₂N₅O₂
Molecular Weight:345.308
Hs Code.:

Synonyms:(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

Suppliers and Price of (R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

There total 3 articles about (R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1218935-59-1,1217630-38-0
(R)-(+)-2-(2,5-difluorophenyl)pyrrolidine

: 18087-76-8
6-chloro-3-nitroimidazo<1,2-b>pyridazine

: 1218935-61-5
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

Guidance literature:: In butan-1-ol; at 140 ℃; sealed in a pressure reaction tube;

Reference yield:

: (R)-N-((R)-1-(2,5-difluorophenyl)-3-(1,3-dioxane-2-yl)propyl)-2-methylpropane-2-sulfinamide

: 1218935-61-5
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / trifluoroacetic acid / 1 h / 20 °C

1.2: 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 110 °C

With water; N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; trifluoroacetic acid;

Reference yield:

: 2646-90-4
2,5-difluorobenzaldehyde

: 1218935-61-5
(R)-6-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitroimidazo[1,2-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dichloromethane / 3 h / 50 °C

2.1: magnesium; diisobutylaluminium hydride / tetrahydrofuran / 1 h / 40 - 50 °C

2.2: 2 h / -30 - 20 °C

3.1: water / trifluoroacetic acid / 1 h / 20 °C

3.2: 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 110 °C

With water; diisobutylaluminium hydride; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; trifluoroacetic acid;