Chemical Property of Butylidenephthalide
Chemical Property:
- Vapor Pressure:0.000545mmHg at 25°C
- Melting Point:82.5°C
- Refractive Index:n20/D 1.577(lit.)
- Boiling Point:312°Cat760mmHg
- Flash Point:113 ºC
- PSA：26.30000
- Density:1.204 g/cm3
- LogP:2.99800
- Storage Temp.:Refrigerator
- Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly)
- XLogP3:3.2
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:188.083729621
- Heavy Atom Count:14
- Complexity:255
- Purity/Quality:
-
≥98% *data from raw suppliers
3-Butylidenephthalide *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
22
- Safety Statements:
23
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCCC=C1C2=CC=CC=C2C(=O)O1
- Isomeric SMILES:CCC/C=C/1\C2=CC=CC=C2C(=O)O1
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Description
N-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder. It is a bioactive phthalide compound of Chuanxiong rhizoma, a Chinese herbal medicine used for treating headache obtained from the root of Ligusticum chuanxiong Hort. It has found that it can regulate tumor stem cell genes EZH2/AXL and reduced its migration and invasion in glioblastoma. Moreover, it can induce apoptosis in the A549 human lung adenocarcinoma cell line by coupled down-regulation of AP-2a and telomerase activity. Therefore, it is a potential cancer chemotherapy drug. Moreover, It can also exhibit protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3. Finally, it has certain antiplatelet effect.
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Uses
3-Butylidenephthalide is a phthalide derivative useful for control of sensation disorder and olfaction disorder.
