2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

Base Information

Chemical Name:2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride
CAS No.:1459732-41-2
Molecular Formula:C₂₃H₁₆ClN₅O*ClH
Molecular Weight:450.327
Hs Code.:

Synonyms:2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

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Chemical Property of 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

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Technology Process of 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

There total 13 articles about 2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1350428-31-7
2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide

: 1459732-41-2
2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.25h;

Reference yield:

: 5382-43-4
quinoline-6-carboxamide

: 1459732-41-2
2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine; trifluoroacetic anhydride / chloroform / 1.5 h / 10 °C

2: ammonia; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

3: sodium carbonate / ethanol / 12 h / 0 - 20 °C

4: tin(ll) chloride; hydrogenchloride / water / 2 h / 20 °C

5: 12 h / 100 °C

6: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.75 h / 100 °C / Inert atmosphere; Microwave irradiation

7: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic anhydride; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; chloroform; water;

Reference yield:

: 23395-72-4
quinoline-6-carbonitrile

: 1459732-41-2
2-chloro-4-(3-(quinolin-6-ylmethyl)-3H-imidazo[4,5-b]pyridin-5-yl)benzamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: ammonia; hydrogen / methanol / 16 h / 20 °C / 760.05 Torr

2: sodium carbonate / ethanol / 12 h / 0 - 20 °C

3: tin(ll) chloride; hydrogenchloride / water / 2 h / 20 °C

4: 12 h / 100 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.75 h / 100 °C / Inert atmosphere; Microwave irradiation

6: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.25 h / 0 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonia; hydrogen; sodium carbonate; potassium carbonate; tin(ll) chloride; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; water;