1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea

Base Information

Chemical Name:1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea
CAS No.:1416946-01-4
Molecular Formula:C₁₇H₁₄BrF₆N₃O
Molecular Weight:470.212
Hs Code.:

Synonyms:1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea

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Chemical Property of 1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea

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Technology Process of 1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea

There total 6 articles about 1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 125278-10-6,779303-24-1
(S)-1,1,1-trifluoropropan-2-amine

: (S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methanamine hydrochloride

: 530-62-1
1,1'-carbonyldiimidazole

: 1416946-01-4
1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea

Guidance literature:: (S)-1,1,1-trifluoropropan-2-amine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

(S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methanamine hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00518

Reference yield:

: 405174-97-2
3-bromopicolinaldehyde

: 1416946-01-4
1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(II) sulfate / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: magnesium / diethyl ether / 4 h / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane / 1 h / Inert atmosphere

4.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

With hydrogenchloride; copper(II) sulfate; magnesium; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/acs.jmedchem.8b00518

Reference yield:

: 38749-79-0
3-bromo-2-picoline

: 1416946-01-4
1-((S)-(3-bromopyridin-2-yl)(4-(trifluoromethyl)phenyl)methyl)-3-((S)-1,1,1-trifluoropropan-2-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 30 h / Reflux; Inert atmosphere

2.1: morpholine / 1 h / 60 °C / Inert atmosphere

2.2: pH 4

3.1: copper(II) sulfate / dichloromethane / 16 h / 20 °C / Inert atmosphere

4.1: magnesium / diethyl ether / 4 h / Inert atmosphere

4.2: 1 h / -78 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 1 h / Inert atmosphere

6.1: dichloromethane / 1 h / 20 °C / Inert atmosphere

6.2: 20 °C / Inert atmosphere

With morpholine; hydrogenchloride; N-Bromosuccinimide; copper(II) sulfate; magnesium; dibenzoyl peroxide; In 1,4-dioxane; tetrachloromethane; diethyl ether; dichloromethane;
DOI:10.1021/acs.jmedchem.8b00518