(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Base Information

Chemical Name:(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
CAS No.:1452391-04-6
Molecular Formula:C₃₄H₃₇N₅O₆
Molecular Weight:611.698
Hs Code.:

Synonyms:(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

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Chemical Property of (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

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Technology Process of (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

There total 5 articles about (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1452391-02-4
(S)-N-(6-(benzyloxy)-9-(4-(bis(4-methoxyphenyl)(phenyl)-methoxy)-2-hydroxybutyl)-9H-purin-2-yl)isobutyramide

: 1452391-04-6
(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 5h; Inert atmosphere;
DOI:10.1039/c3ob41244j

Reference yield:

: 1452390-84-9
(S)-2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)oxirane

: 1452391-04-6
(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 12 h / 110 °C

2.1: pyridine / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 0 °C

3.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; sodium hydride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c3ob41244j

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 1452391-04-6
(S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide / N,N-dimethyl-formamide

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 12 h / 110 °C

4.1: pyridine / 2 h / 0 - 20 °C / Inert atmosphere

4.2: 4 h / 0 °C

5.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 5 h / Inert atmosphere

With pyridine; palladium 10% on activated carbon; hydrogen; sodium hydride; dimethyl sulfoxide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/c3ob41244j