Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

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Chemical Name:Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester
CAS No.:94219-49-5
Molecular Formula:C₂₉H₃₄N₄O₅
Molecular Weight:518.613
Hs Code.:

Synonyms:Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

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Chemical Property of Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

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Technology Process of Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

There total 8 articles about Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 93-97-0
benzoic acid anhydride

: 94192-60-6
N-cyclohexyl-N-(2-hydroxyethyl)-4-(2-oxo-1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-7-yl)oxybutyramide

: 94219-49-5
Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Guidance literature:: With dmap; In pyridine; for 1h; Ambient temperature;
DOI:10.1021/jm00385a012

Reference yield:

: 2842-38-8
cyclohexyl(2-(hydroxy)ethyl)amine

: 94219-49-5
Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Na₂CO₃ / tetrahydrofuran / 2 h / Ambient temperature

2: 1.) AcONa / ethanol / 0.5 h

3: NaBH₃CN / ethanol / 3 h

4: H₂ / 10percent Pd/C / ethanol

5: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

6: 81 percent / DMAP / pyridine / 1 h / Ambient temperature

With dmap; ammonium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; sodium carbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; ethanol;
DOI:10.1021/jm00385a012

Reference yield:

: 94193-39-2
N-Cyclohexyl-4-(3-formyl-4-nitro-phenoxy)-N-(2-hydroxy-ethyl)-butyramide

: 94219-49-5
Benzoic acid 2-{cyclohexyl-[4-(2-oxo-1,2,3,5-tetrahydro-imidazo[2,1-b]quinazolin-7-yloxy)-butyryl]-amino}-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AcONa / ethanol / 0.5 h

2: NaBH₃CN / ethanol / 3 h

3: H₂ / 10percent Pd/C / ethanol

4: 2.) conc. aq. NH₃ / 1.) EtOH, RT, overnight, 2.) EtOH, RT, 30 min

5: 81 percent / DMAP / pyridine / 1 h / Ambient temperature

With dmap; ammonium hydroxide; hydrogen; sodium acetate; sodium cyanoborohydride; palladium on activated charcoal; In pyridine; ethanol;
DOI:10.1021/jm00385a012