(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆-methyladenosine cyclic 3',5'-N-benzylphosphoramidate

Base Information

• Chemical Name: (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆-methyladenosine cyclic 3',5'-N-benzylphosphoramidate
• CAS No.: 1351069-96-9
• Molecular Formula: C₂₈H₃₇N₆O₆PSi
• Molecular Weight: 612.698

Synonyms:(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆-methyladenosine cyclic 3',5'-N-benzylphosphoramidate

Chemical Property of (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆-methyladenosine cyclic 3',5'-N-benzylphosphoramidate

Chemical Property:

Purity/Quality:

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Technology Process of (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆-methyladenosine cyclic 3',5'-N-benzylphosphoramidate

There total 2 articles about (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N₆-methyladenosine cyclic 3',5'-N-benzylphosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-92-5) + methylamine (74-89-5) → (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N6-methyladenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-96-9)

Guidance literature:

With pyridine; In water; at 20 ℃; for 20h;

DOI:10.1016/j.ejmech.2011.10.003

Reference yield:

(SP)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate (872025-84-8) → (S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-N6-methyladenosine cyclic 3',5'-N-benzylphosphoramidate (1351069-96-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 20 h / 95 °C

2: pyridine / water / 20 h / 20 °C

With pyridine; In water;

DOI:10.1016/j.ejmech.2011.10.003

upstream raw materials:

(S_P)-2'-O-(tert-butyldimethylsilyl)-8-(2-furyl)adenosine-3',5'-cyclic N-benzylphosphoramidate

(S(P))-2'O-(tert-butyldimethylsilyl)-8-(2-furyl)-6-desamino-6-(1,2,4-triazol-4-yl)adenosine cyclic 3',5'-N-benzylphosphoramidate

methylamine

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