ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Base Information

Chemical Name:ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate
CAS No.:1616290-25-5
Molecular Formula:C₂₈H₃₃BrN₂O₇S
Molecular Weight:621.549
Hs Code.:

Synonyms:ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

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Chemical Property of ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

There total 13 articles about ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1616290-23-3
ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

: 1616290-25-5
ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Guidance literature:: With phosphoric acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 1616290-25-5
ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1: silver(l) oxide / toluene / 20 h / 110 °C

2: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3: methanol / 1 h / 20 °C

4: methanol; sodium cyanoborohydride / 0 - 20 °C

5: triethylamine / dichloromethane / 18 h / 20 °C

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

7: phosphoric acid / dichloromethane / 4 h / 20 °C

With methanol; di-isopropyl azodicarboxylate; phosphoric acid; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 721959-71-3
2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

: 1616290-25-5
ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 1 h / 20 °C

2: methanol; sodium cyanoborohydride / 0 - 20 °C

3: triethylamine / dichloromethane / 18 h / 20 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

5: phosphoric acid / dichloromethane / 4 h / 20 °C

With methanol; di-isopropyl azodicarboxylate; phosphoric acid; sodium cyanoborohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;