ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Base Information

Chemical Name:ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate
CAS No.:1616290-23-3
Molecular Formula:C₃₃H₄₁BrN₂O₉S
Molecular Weight:721.667
Hs Code.:

Synonyms:ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

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Chemical Property of ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

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Technology Process of ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

There total 11 articles about ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1616288-91-5
tert-butyl ((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)(2-hydroxyethyl)carbamate

: 1616290-22-2
ethyl 3-bromo-2-hydroxy-6-methyl-5-((methylsulfonyl)oxy)benzoate

: 1616290-23-3
ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 1616290-23-3
ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: silver(l) oxide / toluene / 20 h / 110 °C

2: diisobutylaluminium hydride / toluene; dichloromethane / 3 h / 0 - 20 °C

3: methanol / 1 h / 20 °C

4: methanol; sodium cyanoborohydride / 0 - 20 °C

5: triethylamine / dichloromethane / 18 h / 20 °C

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With methanol; di-isopropyl azodicarboxylate; diisobutylaluminium hydride; sodium cyanoborohydride; triethylamine; triphenylphosphine; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 721959-71-3
2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde

: 1616290-23-3
ethyl 2-(2-(((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)((tert-butoxy)carbonyl)amino)ethoxy)-3-bromo-6-methyl-5-((methylsulfonyl)oxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 1 h / 20 °C

2: methanol; sodium cyanoborohydride / 0 - 20 °C

3: triethylamine / dichloromethane / 18 h / 20 °C

4: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C

With methanol; di-isopropyl azodicarboxylate; sodium cyanoborohydride; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;