(S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol

Base Information

Chemical Name:(S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol
CAS No.:1425504-51-3
Molecular Formula:C₁₅H₂₂F₂N₂O₂
Molecular Weight:300.349
Hs Code.:

Synonyms:(S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol

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Chemical Property of (S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol

Chemical Property:

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Technology Process of (S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol

There total 3 articles about (S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1425504-50-2
(S)-1-(3-(3,4-difluorophenoxy)-2-hydroxypropyl)piperidin-4-one

: 593-51-1
methylamine hydrochloride

: 1425504-51-3
(S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol

Guidance literature:: (S)-1-(3-(3,4-difluorophenoxy)-2-hydroxypropyl)piperidin-4-one; methylamine hydrochloride; With titanium(IV) isopropylate; triethylamine; In ethanol; at 20 ℃; for 8h;

With sodium tetrahydroborate; In ethanol; for 8h;
DOI:10.1021/ol302601b

Reference yield:

: 41661-47-6
piperidin-4-one

: 1425504-51-3
(S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / 1 h / 20 °C

1.2: 5 h / 90 °C

2.1: titanium(IV) isopropylate; triethylamine / ethanol / 8 h / 20 °C

2.2: 8 h

With titanium(IV) isopropylate; triethylamine; In ethanol; water;
DOI:10.1021/ol302601b

Reference yield:

: 2713-33-9
3,4-difluorophenol

: 1425504-51-3
(S)-1-(3,4-difluorophenoxy)-3-(4-(methylamino)piperidin-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / 1 h / 20 °C

1.2: 5 h / 90 °C

2.1: titanium(IV) isopropylate; triethylamine / ethanol / 8 h / 20 °C

2.2: 8 h

With titanium(IV) isopropylate; triethylamine; In ethanol; water;
DOI:10.1021/ol302601b